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This combination is highly scrutinized for its capacity to accelerate the proliferation of capillaries into ischemic or avascular tissue zones

FIGURE 1 3.1 Sepsis-associated AKI (S-AKI) Sepsis, characterized as a systemic inflammatory response syndrome associated with infection, frequently leads to multiple organ dysfunction, particularly impacting the kidneys and resulting in sepsis-associated AKI (S-AKI)

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This damage allows for the continued influx of endotoxins, primarily LPS, into systemic circulation, stimulating the production of proinflammatory cytokines and other immune responses [42]